Selected by the Raiders in the fifth round (149th overall) of the 2019 NFL Draft, April 27, 2019. Renfrow is the third college football player in his family. His father, Tim, played at Wofford, but did have an interception against Clemson in his career. His brother, Cole, played tight end for the Tigers. Renfrow's hard work and bloodlines helped him stand out as a redshirt freshman walk-on, starting 10 games and catching 33 passes for 492 yards and five touchdowns. He was the Co-Player of the Game (with quarterback Deshaun Watson) in the national title game against Alabama. Renfrow missed time in the Clemson's national championship season, but still started 9 of 11 games (44-495, six TD) and shared the team's Hustle Award on offense with left tackle Mitch Hyatt. He was a third-team All-ACC pick as the Tigers' top receiver in 2017, starting 13 of 14 games played and grabbing 60 passes for 602 yards and three scores. Though Renfrow became somewhat less of a factor on offense in 2018 due to the Tigres' young talent at the position, ACC coaches voted him third-team all-conference as the 15-game starter corralled 49 passes for 534 yards (10.9 average) and one touchdown. His career accomplishments earned him the Brandon Burlsworth Trophy as the top senior who began his career as a walk-on.