All-Time Record: Raiders lead series 21-19 (.525)
2021 record: 11-6
Division Finish: (1st/AFC East)
Playoffs: Lost in AFC Divisional Game
Head Coach: Sean McDermott
Key additions: LB Von Miller, TE O.J. Howard, CB Kaair Elam, WR Jamison Crowder, RB Duke Johnson, QB Case Keenum, DT DaQuan Jones, P Matt Araiza
Notable players: QB Josh Allen, WR Stefon Diggs, LB Tremaine Edmunds, CB Tre'Davious White, S Jordan Poyer, TE Dawson Knox, DE AJ Epenesa, T Dion Dawkins, DE Greg Rousseau
Key losses: QB Mitchell Trubisky, WR Cole Beasley, OL Daryl Williams, LB A.J. Klein, DE Jerry Hughes, DE Mario Addison
• The first meeting in the all-time series took place on Oct. 23, 1960, when the Bills beat the Raiders in Buffalo, 38-9.