All-Time Record: Raiders lead series 10-8 (.556)
2021 record: 9-8
Division Finish: (2nd/AFC South)
Head Coach: Frank Reich
Key additions: QB Matt Ryan, CB Stephon Gilmore, DE Yannick Ngakoue, WR Alec Pierce
Notable players: DT DeForest Buckner, WR Michael Pittman Jr., CB Kenny Moore II, LB Darius Leonard, OG Quenton Nelson, RB Jonathan Taylor
Key losses: QB Carson Wentz, CB Rock Ya-Sin, CB Xavier Rhodes, RB Marlon Mack
• Las Vegas leads the all-time series 9-8 (.529), with a 1-1 record in the postseason.
• Raiders offensive line coach Tom Cable played one season for the Colts.
• Raiders G Denzelle Good was originally drafted by the Colts in the 2015 NFL Draft, appearing in 26 games with 20 starts until joining the Raiders prior to Week 13 of the 2018 season.
• Raiders DT Johnathan Hankins joined the Raiders after spending the 2017 season in Indianapolis, starting all 15 games he appeared in and recording 44 tackles.