All-Time Record: Series tied 7-7 (.500)
2021 record: 10-7
Division Finish: (3rd/NFC West)
Playoffs: Lost in NFC Championship Game
Head Coach: Kyle Shanahan
Key additions: CB Charvarius Ward, WR Ray-Ray McCloud, DL Drake Jackson
Notable players: QB Jimmy Garoppolo, QB Trey Lance, TE George Kittle, DL Nick Bosa, LB Fred Warner, T Trent Williams, DL Arik Armstead, DL Dee Ford, WR Brandon Aiyuk
Key losses: OG Laken Tomlinson, RB Raheem Mostert, CB K'Waun Williams
• The Silver and Black have matched up against the 49ers 14 times, with the series tied 7-7.
• The Raiders and 49ers first matchup was in 1970.